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Doctors Featured in this Article. Featured Doctors Images. Related Doctors. By Debbe Geiger. Normally, adenoviruses cause respiratory infections in humans. However, this adenovirus has been modified so that it cannot replicate within cells. This means that it cannot cause illness. It simply helps to deliver the vaccine components into your cells before being broken down.

The spike protein is normally found on the outside of the novel coronavirus and is used to bind to host cells. Your cells use the instructions in the genetic material the viral vector provides to produce spike protein, which is then transported to the cell surface.

Your immune system can see the spike protein on the cell surface and identify it as foreign. It produces an immune response, during which antibodies and immune cells that specifically recognize spike protein are made.

Should you come into contact with the novel coronavirus, your immune system will have been primed to recognize and defend against it. Why is this? Early clinical trials tested both a one- and two-dose vaccine regimen. It was found that 90 percent of participants made robust levels of neutralizing antibodies 29 days after the first dose.

Researchers found that levels of these antibodies remained stable 71 days after the first dose. The extent and stability of this response prompted researchers to continue with the one-dose regimen in further trials. Generally speaking, there are three major differences:. By comparison, the rate of fainting after flu vaccination in — was 0. Do not wait for a specific brand. CDC does not recommend mixing products for an initial 2-dose vaccine series or additional doses. Learn more about vaccine safety monitoring after a vaccine is authorized or approved for use.

Forty The most frequent underlying medical conditions among participants were obesity Learn more about demographic information for people who participated in the trials [PDF — 62 pages] external icon. Skip directly to site content Skip directly to page options Skip directly to A-Z link. Section Navigation. Important update: Healthcare facilities. Learn more. To maximize protection from the Delta variant and prevent possibly spreading it to others, get vaccinated as soon as you can and wear a mask indoors in public if you are in an area of substantial or high transmission.

Updated Oct. Mass Vaccination Sites, April Skip directly to site content Skip directly to page options Skip directly to A-Z link.

Section Navigation. Important update: Healthcare facilities. Learn more. To maximize protection from the Delta variant and prevent possibly spreading it to others, get vaccinated as soon as you can and wear a mask indoors in public if you are in an area of substantial or high transmission.

Updated Aug. Minus Related Pages. Most reports of this serious condition, which involves blood clots with low platelets, have been in adult women younger than 50 years old.

However, women younger than 50 years old especially should be aware of the rare but increased risk of this adverse event, and they should know about other available COVID vaccine options for which this risk has not been seen. If you have any questions or concerns, call your doctor, nurse, or clinic.



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